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Top 10 biologics


The top 10 biologics - Ebook

Our Ebook provides and overview of the top 10 biologics and key information regards their application, mode of action and biosimilars.

What's in our Ebook?

Mechanism of action

In our Ebook we provide an overview of the mechanism of action of each our the biologics listed and it's affect on inflammation and respose.


In our Ebook we provide an overview of repurposing of each biologic and associated biosimilars.


Finally, we provide an overview of sales of each biologic, it's manufacturer and the up and coming biosimilars!

Top 10 Biologics in the world - Free Ebook!

What are biologics?

Biological drugs, or biologics, are commonly defined as large, complex, organic molecules (composed of sugars, proteins, or nucleic acids) produced by living organisms (either microorganisms or mammalian cells). Biologics englobe a wide range of products such as vaccines, blood and blood components, allergenics, somatic cells, gene therapy, tissues, and recombinant therapeutic proteins.

In contrast to chemical drugs, whose production processes and structures are relatively well-characterized and uniform, biologics necessitate complex and costly aseptic manufacturing processes and quality controls that are more difficult to scale-up.

The first biologics

The first appearance of biologics on the pharmaceutical market dates back to the 1980s with the development of human growth hormone, insulin and red-blood cell stimulating agents.

Since then, thanks to the advances in genetics, proteomics, cellular biology and biotechnologies that allow researchers to dissect cellular pathways involved in pathological processes, biologics now represent the cutting-edge of biomedical research and the most promising line of treatment in a wide variety of medical indications, including cancers and autoimmune diseases. Noticeably, among the top 10 drugs reported in 2018 by sales, 7 can be considered bona fide biologics.


Here, we propose an overview of the Top 10 Biologics sold in 2018, based on the financial reports published by pharmaceutical companies in early 2019. Comprehensive information about each drug can be accessed through their full prescribing information.