STAT2 Transcription Factor Activity Assay

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SKU:
TFAB00184
€699

Description

ELISA Kit Technical ManualMSDS

STAT2 Transcription Factor activity assay

Product Description:The ELISA Genie STAT2 transcription factor activity assay allows for the detection and qualitative analysis of endogenous levels of activated transcription factors in a variety of nuclear and cell lysates ELISA Genie ELISA kits are designed to significantly reduce experiment Time: and ensure sensitivity and flexibility for high-throughput screening.
Target Synonyms:p113
Detection Target:Phospho-IRAK1(Thr209)
Reactivity:Human, Rat
Pack Size:12 x 8-Well Microstrips
Detection Method:Colorimetric 450 nm
Format:transcription factor activity assay
Storage and Stability Guarantee:4°C/6 Months
Sample Type:Nuclear or cell lysates
Range:See Technical Manual
Time:4.5 hours

STAT2 Transcription Factor activity assay Protein Information

UniProt Protein Function:STAT2: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of many cytokines and growth-factor receptors. Binds to the IFN-stimulated response element (ISRE) and to the Gas element. This multiprotein transcription factor is termed ISGF3. Two alternatively spliced isoforms have been described.
UniProt Protein Details:

Protein type:DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 12q13.3

Cellular Component: cytoplasm; cytosol; nucleoplasm; plasma membrane

Molecular Function:DNA binding; identical protein binding; protein binding; signal transducer activity; transcription factor activity

Biological Process: cytokine and chemokine mediated signaling pathway; defense response to virus; JAK-STAT cascade; positive regulation of defense response to virus by host; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; viral reproduction

NCBI Summary:The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
UniProt Code:P52630
NCBI GenInfo Identifier:1711552
NCBI Gene ID:6773
NCBI Accession:P52630.1
UniProt Secondary Accession:P52630,Q16430, Q16431, Q9UDL4, B4DLC7, G3V2M6,
UniProt Related Accession:P52630
Molecular Weight:97,457 Da
NCBI Full Name:Signal transducer and activator of transcription 2
NCBI Synonym Full Names:signal transducer and activator of transcription 2
NCBI Official Symbol:STAT2
NCBI Official Synonym Symbols:P113; IMD44; ISGF-3; STAT113
NCBI Protein Information:signal transducer and activator of transcription 2
UniProt Protein Name:Signal transducer and activator of transcription 2
UniProt Synonym Protein Names:p113
Protein Family:Signal transducer and activator of transcription
UniProt Gene Name:STAT2
UniProt Entry Name:STAT2_HUMAN
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