p62 Dok In-Cell ELISA

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p62 Dok In-Cell ELISA

Product DescriptionThe p62 Dok Colorimetric In-Cell ELISA Kit allows for qualitative detection of p62Dok in plated and fixed cells.
Target SynonymsDocking protein 1; Downstream of tyrosine kinase 1; p62(dok) pp62; DOK1
Detection TargetPhospho-IRAK1(Thr209)
ReactivityH, M, R
Pack Size1 x 96 assays
Detection MethodColorimetric 450 nm
FormatIn-Cell ELISA
Storage and Stability Guarantee4°C/6 Months
Sample TypePlated & fixed cells
Range5000 cells/well minimum
Time4.5 hours
SwissProt IDQ99704
NCBI Gene ID1796

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.

Post-translational modifcation Constitutively tyrosine-phosphorylated. Phosphorylated by TEC. Phosphorylated by LYN. Phosphorylated on tyrosine residues by the insulin receptor kinase. Results in the negative regulation of the insulin signaling pathway. Phosphorylated on tyrosine residues by SRMS.

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