Meis1 Transcription Factor Activity Assay

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SKU:
TFAB00133
€699

Description

ELISA Kit Technical ManualMSDS

Meis1 Transcription Factor activity assay

Product Description:The ELISA Genie Meis1 transcription factor activity assay allows for the detection and qualitative analysis of endogenous levels of activated transcription factors in a variety of nuclear and cell lysates ELISA Genie ELISA kits are designed to significantly reduce experiment Time: and ensure sensitivity and flexibility for high-throughput screening.
Target Synonyms:
Detection Target:Phospho-IRAK1(Thr209)
Reactivity:Human, Mouse
Pack Size:12 x 8-Well Microstrips
Detection Method:Colorimetric 450 nm
Format:transcription factor activity assay
Storage and Stability Guarantee:4°C/6 Months
Sample Type:Nuclear or cell lysates
Range:See Technical Manual
Time:4.5 hours

Meis1 Transcription Factor activity assay Protein Information

UniProt Protein Function:MEIS1: Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias. Defects in MEIS1 could be a cause of susceptibility to restless legs syndrome type 7 (RLS7). Restless legs syndrome (RLS) is a neurologic sleep/wake disorder characterized by uncomfortable and unpleasant sensations in the legs that appear at rest, usually at night, inducing an irresistible desire to move the legs. The disorder results in nocturnal insomnia and chronic sleep deprivation. Belongs to the TALE/MEIS homeobox family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:DNA-binding

Chromosomal Location of Human Ortholog: 2p14

Molecular Function:protein binding

Biological Process: negative regulation of myeloid cell differentiation

Disease: Restless Legs Syndrome, Susceptibility To, 7

NCBI Summary:Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. [provided by RefSeq, Jul 2008]
UniProt Code:O00470
NCBI GenInfo Identifier:3024112
NCBI Gene ID:4211
NCBI Accession:O00470.1
UniProt Secondary Accession:O00470,A8MV50,
UniProt Related Accession:O00470
Molecular Weight:50,576 Da
NCBI Full Name:Homeobox protein Meis1
NCBI Synonym Full Names:Meis homeobox 1
NCBI Official Symbol:MEIS1
NCBI Protein Information:homeobox protein Meis1
UniProt Protein Name:Homeobox protein Meis1
Protein Family:Homeobox protein
UniProt Gene Name:MEIS1
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