AFX Transcription Factor Activity Assay

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SKU:
TFAB00104
€699

Description

ELISA Kit Technical ManualMSDS

AFX Transcription Factor activity assay

Product Description:The ELISA Genie AFX transcription factor activity assay allows for the detection and qualitative analysis of endogenous levels of activated transcription factors in a variety of nuclear and cell lysates ELISA Genie ELISA kits are designed to significantly reduce experiment Time: and ensure sensitivity and flexibility for high-throughput screening.
Target Synonyms:Fork head domain transcription factor AFX1
Detection Target:Phospho-IRAK1(Thr209)
Reactivity:Human, Mouse, Rat
Pack Size:12 x 8-Well Microstrips
Detection Method:Colorimetric 450 nm
Format:transcription factor activity assay
Storage and Stability Guarantee:4°C/6 Months
Sample Type:Nuclear or cell lysates
Range:See Technical Manual
Time:4.5 hours

AFX Transcription Factor activity assay Protein Information

UniProt Protein Function:FOXO4: transcription factor AFX1 containing 1 fork-head domain. May play a role in the insulin signaling pathway. Involved in acute leukemias by a chromosomal translocation t(X;11)(q13;q23) that involves MLLT7 and MLL/HRX. The result is a rogue activator protein. Two splice-variant isoforms have been described.
UniProt Protein Details:

Protein type:Oncoprotein; Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: Xq13.1

Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus

Molecular Function:beta-catenin binding; DNA binding; enzyme binding; identical protein binding; protein binding; sequence-specific DNA binding; transcription factor activity; transcription factor binding

Biological Process: cell cycle arrest; insulin receptor signaling pathway; negative regulation of angiogenesis; negative regulation of cell proliferation; negative regulation of smooth muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; stem cell differentiation; transcription from RNA polymerase II promoter

NCBI Summary:This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
UniProt Code:P98177
NCBI GenInfo Identifier:110825720
NCBI Gene ID:4303
NCBI Accession:P98177.5
UniProt Secondary Accession:P98177,O43821, Q13720, Q3KPF1, Q8TDK9, B7WPJ7,
UniProt Related Accession:P98177
Molecular Weight:47,941 Da
NCBI Full Name:Forkhead box protein O4
NCBI Synonym Full Names:forkhead box O4
NCBI Official Symbol:FOXO4
NCBI Official Synonym Symbols:AFX; AFX1; MLLT7
NCBI Protein Information:forkhead box protein O4
UniProt Protein Name:Forkhead box protein O4
UniProt Synonym Protein Names:Fork head domain transcription factor AFX1
Protein Family:Forkhead box protein
UniProt Gene Name:FOXO4
UniProt Entry Name:FOXO4_HUMAN
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